About Kaylie L N Lam
Dr. Lam developed the passion for microbiology while attending Nanyang Technological University (NTU), Singapore where she earned her B.Sc. in 2014. Following her passion, she went on to pursue her Ph.D. in Singapore Centre for Environmental Life Science Engineering (SCELSE), Singapore, where she studied the role of iron on Enterococci physiology. Upon graduation in 2019, she joined the Lemos-Abranches lab to further characterize the importance of metal uptake systems in E. faecalis, and its relevance in diabetic wound infections. The discoveries made during her pre-doctoral and post-doctoral training fueled her passion in understanding the roles of extracellular metabolites/molecules (trace metals, secreted messenger nucleotide) that potentially influences host-pathogen interactions and consequently host nutritional immunity. She aim to establish herself as an independent principal investigator focusing on understanding microbial pathogenesis, particularly in opportunistic pathogens residing with human microbiome and developing alternative therapies using unconventional approaches to curb the current global problem of antimicrobial resistance.
The emergence of Enterococci-associated infections and the rising problem of antibiotic resistance has made clinical interventions a big challenge globally. Understanding the role of metal acquisition, which drives virulence and survival during infection, will provide insights into design of new therapeutic targets. Using interdisciplinary approaches, such as basic microbiological techniques and analyzing mice immunological profiles, my research focus on understanding the role of iron acquisition in Enterococcus faecalis, and how this ability influences host immune response during wound infections.
- Clinical Microbiology
- Gut Microbiome
- Host-pathogen interaction
- Molecular genetics and biology of pathogenic bacteria and their drug resistance