Kaylie L N Lam

Kaylie L N Lam, B.Sc., Ph.D.

Postdoctoral Associate

Department: DN-ORAL BIOLOGY
Business Phone: (352) 328-4319
Business Email: llam1@ufl.edu

About Kaylie L N Lam

Dr. Lam developed the passion for microbiology while attending Nanyang Technological University (NTU), Singapore where she earned her B.Sc. in 2014. Following her passion, she went on to pursue her Ph.D. in Singapore Centre for Environmental Life Science Engineering (SCELSE), Singapore, where she studied the role of iron on Enterococci physiology. Upon graduation in 2019, she joined the Lemos-Abranches lab to further characterize the importance of metal uptake systems in E. faecalis, and its relevance in diabetic wound infections. The discoveries made during her pre-doctoral and post-doctoral training fueled her passion in understanding the roles of extracellular metabolites/molecules (trace metals, secreted messenger nucleotide) that potentially influences host-pathogen interactions and consequently host nutritional immunity. She aim to establish herself as an independent principal investigator focusing on understanding microbial pathogenesis, particularly in opportunistic pathogens residing with human microbiome and developing alternative therapies using unconventional approaches to curb the current global problem of antimicrobial resistance.

Related Links:

Accomplishments

Science Improving Life Symposium Travel Grant
2018 · Nanyang Technological University
Gordon Research Conference Travel Grant
2017 ·  Gordon Research Conference

Research Profile

The emergence of Enterococci-associated infections and the rising problem of antibiotic resistance has made clinical interventions a big challenge globally. Understanding the role of metal acquisition, which drives virulence and survival during infection, will provide insights into design of new therapeutic targets. Using interdisciplinary approaches, such as basic microbiological techniques and analyzing mice immunological profiles, my research focus on understanding the role of iron acquisition in Enterococcus faecalis, and how this ability influences host immune response during wound infections.

Open Researcher and Contributor ID (ORCID)

0000-0003-0568-8628

Areas of Interest
  • Clinical Microbiology
  • Gut Microbiome
  • Host-pathogen interaction
  • Immunotherapy
  • Molecular genetics and biology of pathogenic bacteria and their drug resistance

Publications

2023
An RNA modification enzyme directly senses reactive oxygen species for translational regulation in Enterococcus faecalis
Nature Communications. 14(1) [DOI] 10.1038/s41467-023-39790-x. [PMID] 37433804.
2023
Identification of Multiple Iron Uptake Mechanisms in Enterococcus faecalis and Their Relationship to Virulence
Infection and Immunity. 91(4) [DOI] 10.1128/iai.00496-22. [PMID] 36912636.
2022
Dual species biofilms are enhanced by metabolite cross-feeding.
Trends in microbiology. 30(9):809-811 [DOI] 10.1016/j.tim.2022.07.003. [PMID] 35871025.
2022
Enterococcus faecalis Antagonizes Pseudomonas aeruginosa Growth in Mixed-Species Interactions
Journal of Bacteriology. 204(7) [DOI] 10.1128/jb.00615-21. [PMID] 35758750.
2022
The AdcACB/AdcAII system is essential for zinc homeostasis and an important contributor of Enterococcus faecalis virulence
Virulence. 13(1):592-608 [DOI] 10.1080/21505594.2022.2056965. [PMID] 35341449.
2021
c-di-AMP Is Essential for the Virulence of Enterococcus faecalis
Infection and Immunity. 89(11) [DOI] 10.1128/iai.00365-21.
2021
The composition and function of Enterococcus faecalis membrane vesicles
microLife. 2 [DOI] 10.1093/femsml/uqab002.
2020
Enterococcus faecalis Manganese Exporter MntE Alleviates Manganese Toxicity and Is Required for Mouse Gastrointestinal Colonization
Infection and Immunity. 88(6) [DOI] 10.1128/iai.00058-20.
2019
Biofilm-associated infection by enterococci
Nature Reviews Microbiology. 17(2):82-94 [DOI] 10.1038/s41579-018-0107-z.
2018
Extracellular Electron Transfer Powers Enterococcus faecalis Biofilm Metabolism
mBio. 9(2) [DOI] 10.1128/mbio.00626-17.
Sortase-assembled pili promote extracellular electron transfer and iron acquisition inEnterococcus faecalisbiofilm
. [DOI] 10.1101/601666.

Grants

Jan 2022 ACTIVE
Enterococcal metal binding proteins as therapeutic targets
Role: Principal Investigator
Funding: AMER HEART ASSOCIATION

Education

PhD of Biological Sciences
2014-2018 · Nanyang Technological University, Singapore
Bachelors of Biological Sciences (Hons)
2010-2014 · Nanyang Technological University, Singapore

Contact Details

Phones:
Business:
(352) 328-4319
Emails:
Business:
llam1@ufl.edu
Addresses:
Business Mailing:
1395 CENTER DR
GAINESVILLE FL 32611